Pancreas organogenesis: Approaches to elucidate the role of epithelial-mesenchymal interactions.

Sakhneny L, Khalifa-Malka L, Landsman L.

Semin Cell Dev Biol. 2018 Aug 29. pii: S1084-9521(17)30552-9. doi: 10.1016/j.semcdb.2018.08.012. [Epub ahead of print] Review.

Pancreatic Pericytes Support β-Cell Function in a Tcf7l2-Dependent Manner.

Sakhneny L, Rachi E, Epshtein A, Guez HC, Wald-Altman S, Lisnyansky M, Khalifa-Malka L, Hazan A, Baer D, Priel A, Weil M, Landsman L.

Diabetes. 2018 Mar;67(3):437-447. doi: 10.2337/db17-0697. Epub 2017 Dec 15.

Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer.

Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Tiram G, Blau R, Ofek P, Lee JS, Ruppin E, Landsman L, Barshack I, Golan T, Merquiol E, Blum G, Satchi-Fainaro R.

Nat Commun. 2018 Jan 2;9(1):16. doi: 10.1038/s41467-017-02283-9.

Neonatal pancreatic pericytes support β-cell proliferation.

Epshtein A, Rachi E, Sakhneny L, Mizrachi S, Baer D, Landsman L.

Mol Metab. 2017 Oct;6(10):1330-1338. doi: 10.1016/j.molmet.2017.07.010. Epub 2017 Jul 19.

PMID: 29031732

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry.
Epshtein A, Sakhneny L, Landsman L.
J Vis Exp. 2017 Jan 28;(119). doi: 10.3791/55344.
PMID: 28190046

Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner.
Hibsher D, Epshtein A, Oren N, Landsman L.
Sci Rep. 2016 Nov 28;6:38008. doi: 10.1038/srep38008.
PMID: 27892540 Free PMC Article

Islet Pericytes Are Required for β-Cell Maturity.
Sasson A, Rachi E, Sakhneny L, Baer D, Lisnyansky M, Epshtein A, Landsman L.
Diabetes. 2016 Oct;65(10):3008-14. doi: 10.2337/db16-0365.
PMID: 27388217

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation.

Russ HA, Landsman L, Moss CL, Higdon R, Greer RL, Kaihara K, Salamon R, Kolker E, Hebrok M.
Stem Cells Int. 2016;2016:6183562. doi: 10.1155/2016/6183562.
PMID: 26681951

On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells.

Avraham-Davidi I, Yona S, Grunewald M, Landsman L, Cochain C, Silvestre JS, Mizrahi H, Faroja M, Strauss-Ayali D, Mack M, Jung S, Keshet E. J Exp Med. 2013 Nov 18;210(12):2611-25.

Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs.

Guo T, Landsman L, Li N, Hebrok M.
Diabetes. 2013 May;62(5):1581-92. doi: 10.2337/db12-0167.

Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.

Landsman L, Parent A, Hebrok M. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17010-5. Epub 2011 Oct 3.

Pancreatic mesenchyme regulates epithelial organogenesis throughout development.

Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M. PLoS Biol. 2011 Sep;9(9):e1001143. Epub 2011 Sep 6.

Probing in vivo origins of mononuclear phagocytes by conditional ablation and reconstitution.

Varol C, Landsman L, Jung S. Methods Mol Biol. 2009;531:71-87.

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

Landsman L*, Bar-On L*, Zernecke A*, Kim KW, Krauthgamer R, Shagdarsuren E, Lira SA, Weissman IL, Weber C, Jung S. Blood. 2009 Jan 22;113(4):963-72. Epub 2008 Oct 29. *Equal contribution

Stabilization of beta-catenin induces pancreas tumor formation.

Heiser PW, Cano DA, Landsman L, Kim GE, Kench JG, Klimstra DS, Taketo MM, Biankin AV, Hebrok M. Gastroenterology. 2008 Oct;135(4):1288-300. Epub 2008 Jul 9.

Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration.

Ravid D, Chuderland D, Landsman L, Lavie Y, Reich R, Liscovitch M. Exp Cell Res. 2008 Sep 10;314(15):2762-73. Epub 2008 Jun 12.

Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages.

Landsman L, Jung S. J Immunol. 2007 Sep 15;179(6):3488-94.

Distinct differentiation potential of blood monocyte subsets in the lung.

Landsman L, Varol C, Jung S. J Immunol. 2007 Feb 15;178(4):2000-7.

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells.

Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, Margalit R, Kalchenko V, Geissmann F, Jung S. J Exp Med. 2007 Jan 22;204(1):171-80. Epub 2006 Dec 26.

Transepithelial pathogen uptake into the small intestinal lamina propria.

Vallon-Eberhard A*, Landsman L*, Yogev N, Verrier B, Jung S. J Immunol. 2006 Feb 15;176(4):2465-9. *Equal contribution

VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells.

Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S, Chimenti S, Landsman L, Abramovitch R, Keshet E. Cell. 2006 Jan 13;124(1):175-89.

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.

Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. Science. 2005 Jan 14;307(5707):254-8.

MRI and fluorescence microscopy of the acute vascular response to VEGF165: vasodilation, hyper-permeability and lymphatic uptake, followed by rapid inactivation of the growth factor.

Dafni H, Landsman L, Schechter B, Kohen F, Neeman M. NMR Biomed. 2002 Apr;15(2):120-31.

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation.

Lavon I, Goldberg I, Amit S, Landsman L, Jung S, Tsuberi BZ, Barshack I, Kopolovic J, Galun E, Bujard H, Ben-Neriah Y. Nat Med. 2000 May;6(5):573-7.